Keyong Hou, Professor, PhD
Distinguished Young Professor of Shandong University
Young Taishan Scholars
Address: Environmental Research Institute of Shandong University, 72 Binhai Road, Qingdao, Shandong Province
Office：K6-332
Tel: 0532-58631956.
E-mail：houky@sdu.edu.cn
Research Interests:
Prof. Hou’ research interests development and application of new mass spectrometer and analytical methods for the real-time analysis of environmental pollutants, national security check, industrial process analysis. In the past ten years, Prof. Hou has successively presided four National Natural Science Foundation projects, 1 National Major Instrument Special Project, 1 National Major R&D Program Sub-project, 1 National "863" Resource and Environment Sub-project, 1 Chinese Academy of Sciences Instrument Development Project. In the field of analytical chemistry and environment analysis, Prof. Hou has more than 70 SCI papers, 22 granted patents, and over 30 keynote lectures at international and domestic conferences. The detail of research interests are as following:
1. Development and application of new technologies and methods for on-site detection of environmental pollutants
2. Research on new technologies and methods for detecting atmospheric free radicals and key species of nucleation
3. On line monitoring of VOCs and its secondary pollution mechanism
4. Miniaturization technology of mass spectrometry and its application in security check
Education:
2002.9-2008.1, Ph.D., analytical chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
1998.7-2002.7, B.S. chemistry, Qingdao University
Work experience:
2019.11-now: Professor, Environmental Research Institute, Shandong University
2016.6-2019.11, Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2013.1-2016.12, Member of Chinese Academy of Sciences youth Promotion Association
2011.10-2016.6, Associate professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2009.10-2011.4, Postdoctoral fellow, Research group of R. Graham Cooks, Purdue University.
Published papers：
1. Chuting,Xu, Weiming,Wang, Shuang Wang，Keyong Hou*，Haiyang Li*, Potential analytical methods for on-site oral drug test: Recent developments and applications, TrAC, 2019, 115649
2. Weiming,Wang, Shuang Wang，Chuting Xu，Hong Li，Yuming Xing，Keyong Hou*，Haiyang Li*, Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection，Anal. Chem. 2019,91,10212-10220
3. Shuang Wang, Weimin Wang,Hong Li, Yuming Xing, Keyong Hou,* and Haiyang Li*, Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer, Anal. Chem., 2019,91,3845-3852
4. Chenxin Wu, Wei Liu,Jichun Jiang, Yan Wang, Keyong Hou *,and Haiyang Li*, An in-source helical membrane inlet single photon ioni-zation time of flight mass spectrometer for automatic monitoring of trace VOCs in water at minutes resolution，Talanta，2019，42,46-51
5. Yan Wang, Lei Hua, Qingyun Li, Jichun Jiang, Keyong Hou, Chenxin Wu, and Haiyang Li *，Direct Detection of Small n-Alkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure，Anal. Chem., 2018, 90 (8), pp 5398–5404
6. Yan Wang, Lei hua, Jichun Jiang, Yuanyuan Xie, Keyong Hou, Qingyun Li, Chenxin Wu and Haiyang Li *, High-pressure photon ionization time-of-flight mass spectrometry combined with dynamic purge-injection for rapid analysis of volatile metabolites in urine. Analytica Chimica Acta. 1008 (2018) 74-81
7. Zhou Lijuan, Jiang Jichun, Zhao Kun, Li Jinxu, Wu Chenxin, Li Haiyang, Tian Di*, Hou Keyong*, “Radiofrequency field enhanced chemical ionization with vacuum ultraviolet lamp for miniature time-of-flight mass spectrometer”. Chinese Chem. Lett., 2018. Volume 29, Issue 5, 707-710
8. Hou Keyong, Li J, Qu T, Tang B, Zhu LP, Huang YG, Li HY*. “Development of a suitcase time-of-flight mass spectrometer for in situ fault diagnosis of SF6‐insulated switchgear by detection of decomposition products”. Rapid Commun. Mass Spectrom., 2016, 30(S1): 38-43.
9. Liu W, Jiang J, Hou Keyong, Weiguo Wang, Yachen Qi, Yan Wang, Yuanyuan Xie, Lei Hua, Haiyang Li *. “Online monitoring of trace chlorinated benzenes in flue gas of municipal solid waste incinerator by windowless VUV lamp single photon ionization TOFMS coupled with automatic enrichment system”. Talanta, 2016, 161: 693-699.
10. Wang Yan, Jiang Jichun, Hua Lei, Keyong Hou, Yuanyuan Xie, Ping Chen, Wei Liu, Qingyun Li, Shuang Wang, and Haiyang Li* , “High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis”. Anal. Chem., 2016, 88(18): 9047-9055.
11. Jichun Jiang, Yan Wang, Keyong Hou, Lei Hua, Ping Chen, Wei Liu , Yuanyuan Xie, Haiyang Li*, “Photoionization-Generated Dibromomethane Cation Chemical Ionization Source for Time-of-Flight Mass Spectrometry and Its Application on Sensitive Detection of Volatile Sulfur Compounds. Anal. Chem. 2016, 88, 5028–5032
12. Yuanyuan Xie, Ping Chen, Lei Hua, Keyong Hou, Yongchao Wang, Haiyan Wang, Haiyang Li*, “Rapid Identification and Quantification of Linear Olefin Isomers by Online Ozonolysis-Single Photon Ionization Time-of-Flight Mass Spectrometry”, J.Am. Soc. Mass Spectrom., 2016, 27(1): 144-152.
13. Wendong Chen, Keyong Hou, Lei Hua, Haiyang Li*, “Dopant-assisted reactive low temperature plasma probe for sensitive and specific detection of explosives”, Analyst, 2015, 140(17): 6025-6030
14. Lei Hua, Keyong Hou, Ping Chen, Yuanyuan Xie, Jichun Jiang, Yan Wang, Weiguo Wang, and Haiyang Li* , “Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds”, Anal. Chem., 2015, 87 (4), pp 2427–2433
15. Chuang Chen, Keyong Hou,Weiguo Wang, Jinghua Li,Haiyang Li*, “Ambient temperature nanoelectrospray ion mobility detector for high performance liquid chromatography in determining amines”, J. Chromatogr. A. 2014; 1358, 192-198.
16. Yuanyuan Xie, Lei Hua, Keyong Hou, Ping Chen, Wuduo Zhao, Wendong Chen, Bangyu Ju, and Haiyang Li*, “Long-Term Real-Time Monitoring Catalytic Synthesis of Ammonia in a Microreactor by VUV-Lamp-Based Charge-Transfer Ionization Time-of-Flight Mass Spectrometry”, Anal. Chem., 2014, 86 (15), pp 7681-7687
17. Wendong Chen, Keyong Hou, Lei Hua, Xingchuang Xiong, Haiyang Li*, “Water-assisted low temperature plasma ionization source for sensitive detection of explosives”, RSC Advances , 2014 , 28, 4, 14791-14794,
18. Ping Chen, Keyong Hou, Lei Hua, Yuanyuan Xie, Wuduo Zhao, Wendong Chen, Chuang Chen, and Haiyang Li*，“Quasi-Trapping Chemical Ionization Source Based on a Commercial VUV Lamp for Time-of-Flight Mass Spectrometry”, Anal. Chem., 2014, 86 (3), pp 1332–1336
19. Shasha Cheng, Weiguo Wang, Qinghua Zhou, Chuang Chen, Liying Peng, Lei Hua, Yang Li, Keyong Hou, and Haiyang Li*, “Fast Switching of CO3–(H2O)n and O2–(H2O)n Reactant Ions in Dopant-Assisted Negative Photoionization Ion Mobility Spectrometry for Explosives Detection”，Anal. Chem., 2014, 86,2687-2693
20. Keyong Hou, Fanglong Li, Wendong Chen, Ping Chen, Yuanyuan Xie , Wuduo Zhao , Lei Hua , Kemei Pei, Haiyang Li* ,“An In-Source Stretched Membrane Inlet for On-Line Analysis of VOCs in Water with Single Photon Ionization TOFMS”, Analyst, 2013,138(17):5826-5831
21. Chen W, Hou Keyong*, Xiong X, Jiang Y, Zhao W, Hua L, Chen P, Xie Y, Wang Z, Li H*. “Non-contact halogen lamp heating assisted LTP ionization miniature rectilinear ion trap: a platform for rapid, on-site explosives analysis”. Analyst, 2013,138(17):5068-73.
22. Shasha Cheng, Jian Dou, Weiguo Wang, Chuang Chen, Lei Hua, Qinghua Zhou, Keyong Hou, Jinghua Li, and Haiyang Li*. “Dopant-Assisted Negative Photoionization IMS for Sensitive Detection of Explosives”, Anal. Chem.,2013, 85, 319-326
23. Xixi Liang, Qinghua Zhou, Weiguo Wang, Xin Wang, Wendong Chen, Chuang Chen,Yang Li, Keyong Hou, Jinghua Li, and Haiyang Li*, “Sensitive Detection of Black Powder by a Stand-Alone Ion Mobility Spectrometer with an Embedded Titration Region”, Anal. Chem.,2013, 85, 4849−4852
24. Qinghao Wu, Lei Hua, Keyong Hou, Huapeng Cui, Haiyang Li*, “Vacuum Ultraviolet Lamp Based Magnetic Field Enhanced Photoelectron Ionization and Single Photon Ionization Source for Online Time-of-Flight Mass Spectrometry”, Anal. Chem., 2011 , Vol 83, 8992-8998
25. Keyong Hou, Wei Xu, R. Graham Cooks*, Zheng Ouyang*, “Sampling Wand for an Ion Trap Mass Spectrometer”, Anal. Chem., 2011, Vol 83 (5), 1857-1861
26. Lei Hua, Qinghao Wu, Keyong Hou*, Huapeng Cui, Ping Chen, Weiguo Wang, Jinghua Li, Haiyang Li*, “Single Photon Ionization and Chemical Ionization Combined Ion Source Based on a Vacuum Ultraviolet Lamp for Orthogonal Acceleration Time-of-Flight Mass Spectrometry”, Anal. Chem. 2011，83(13):5309-5316
27. Chuang Chen, Can Dong, Yongzhai Du, Shasha Cheng, Fenglei Han, Lin Li, Weiguo Wang, Keyong Hou, Haiyang Li*, “Bipolar Ionization Source for Ion Mobility Spectrometry Based on Vacuum Ultraviolet Radiation Induced Photoemission and Photoionization”，Anal. Chem.，2010, Vol 82,4151-4157
Granted patents:
1. Hou Keyong, Dong can, Li Haiyang, Vacuum ultraviolet lamp ionization device in time of flight mass spectrometer, invention patent, patent application No: 200610011793.2, 2009.4.29, authorization
2. Hou Keyong, Li Haiyang, A kind of membrane sampling sample enrichment device for on-line gas analysis mass spectrometry, invention patent, patent application No: 200710011223.8, 2011.12.14, authorization
3. Hou Keyong, Li Haiyang, Micro time of flight mass spectrometry online sample enrichment device, invention patent, patent application No: 200610134947.7, 2011.08.31, authorization
4. Hou Keyong, Hua Lei, Wu Qinghao, Cui Huapeng, Li Haiyang, Hollow cathode discharge vacuum ultraviolet photoionization source in micro mass spectrometer, invention patent, patent application No: 200910265445.1, 2012.11.07, authorization
5. Hou Keyong, Chen Wendong, Li Haiyang, A dielectric barrier discharge mass spectrometry ionization source device with selective detection reagent, invention patent, 201210536370.8, 2015.12.09, authorization
6. Hou Keyong, Chen Wendong, Cui Huapeng, Hua Lei, A shoulder back portable time-of-flight mass spectrometer, invention patent: 201110233344.3, 2015.12.02, authorization
7. Hou Keyong, Zhao wuduo, Chen Wendong, Li Haiyang, A photoionization source in linear acceleration time-of-flight mass spectrometry, invention patent, 201210562884.0, 2016.03.16, authorization
8. Hou Keyong, Cui Huapeng, Hua Lei, Chen Ping, Li Haiyang, A high sensitive ionization source for on-line analysis of explosives and its application, invention patent: 201110233372.5, 2016.03.16, authorization
9. Hou Keyong, Li Fanglong, Chen Wendong, Li Haiyang, An on-line mass spectrometry ionization source inner tubular membrane sampling device, invention patent: 201210234534.1, 2016.06.15, authorization
10. Hou Keyong, Hua Lei, Chen Ping, Cui Huapeng, Li Haiyang, A mass spectrometry ionization source for in situ detection of explosives in large area and its application, invention patent: 201110232457.1, 2015.12.16, authorization
11. Hou Keyong, Li Fanglong, Chen Wendong, Li Haiyang, A direct heating tubular membrane enrichment injection device for on-line mass spectrometry, invention patent: 201210234821.2, 2016.12.21, authorization
12. Hou Keyong, Su Mingyang, Li Haiyang, Chen Ping, Jiang Jichun, Li Jinxu, An internal spiral tubular membrane sampling device for ionization source, invention patent: 201310694028.5, 2017.1.25, authorization
